Impaired Energy Metabolism after Co-Exposure to Leadand Ethanol

Histological evaluation of the thyroid structure after co-exposure to cadmium and ethanol.

The aim of this study was to evaluate the influence of co-exposure to cadmium (Cd) and ethanol on the structure and function of the thyroid. Male Wistar rats were exposed to 50 mg of Cd/dm3 in drinking water and ethanol in a dose of 5 g/kg body wt/24 h (administered intragastrically in two equal doses for 5 days a week) for 12 weeks. The structure of the thyroid was assessed in a light microsco...

Changes of hippocampal neurons after perinatal exposure to ethanol.

The effect of ethanol on the structural development of the central nervous system was studied in offspring of Wistar rats, drinking 20 % ethanol during pregnancy and till the 28th day of their postnatal life. The structural changes in the hippocampus and dentate gyrus were analyzed at the age of 18, 35 and 90 days. A lower width of pyramidal and granular cell layers, cell extinction and fragmen...

Energy metabolism after injury.

Antidepressant Effect of Aminophylline After Ethanol Exposure

This work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in beha...

PHARMACOLOGY AND CELL METABOLISM Lead and Ethanol Co-Exposure Lead to Blood Oxidative Stress and Subsequent Neuronal Apoptosis in Rats

Aims: The present study was aimed at investigating chronic exposure to lead and ethanol, individually and in combination with blood oxidative stress leading to possible brain apoptosis in rats. Methods: Rats were exposed to lead (0.1% w/v in drinking water) or ethanol (1 and 10%) either individually or in combination for four months. Biochemical variables indicative of oxidative stress (blood a...